Kisspeptin-10 (KP-10) is a decapeptide, a chain of 10 amino acids (sequence YNWNSFGLRF), corresponding to the C-terminal active fragment of the larger kisspeptin protein encoded by the KISS1 gene. It is studied in preclinical research as a ligand for the KISS1R receptor (also designated GPR54), most often in models of GnRH-neuron signaling and hypothalamic-axis neuroendocrinology.
Kisspeptin-10 is the shortest fully active fragment of the kisspeptin family in the research literature, which makes it a common tool compound for investigating KISS1R-receptor pharmacology. As supplied for research, Kisspeptin-10 is a lyophilized powder that is water-soluble on reconstitution. Its C-terminal phenylalanine carries an amide group (-NH2), a defining structural feature of the active peptide.
Verified dataVerified compound data
| Property | Value |
|---|---|
| Compound name | Kisspeptin-10 (KP-10, Metastin 45-54) |
| CAS number | 374675-21-5 |
| PubChem CID | 25240297 |
| Molecular formula | C63H83N17O14 |
| Molecular weight | ~1302.5 g/mol |
| Amino acid sequence | Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2 (YNWNSFGLRF) |
| Length | 10 residues (decapeptide), C-terminal amide |
| Physical form | Lyophilized powder |
Data verified against PubChem (CID 25240297, C63H83N17O14) and ChemicalBook (CAS 374675-21-5).
MechanismResearch-context mechanism
In preclinical literature, Kisspeptin-10 is studied as an agonist at the KISS1R receptor (GPR54), a G-protein-coupled receptor expressed on GnRH neurons in animal models. Research suggests that KISS1R activation is associated with downstream GnRH-neuron signaling in the hypothalamic-axis literature. These interactions are characterized at the receptor and neuronal level in in vitro and animal research models; they are not established human-use mechanisms and describe no human outcome.
Research summaryCurrent research summary
Kisspeptin-10 appears across a neuroendocrinology research literature focused on KISS1R-receptor pharmacology. Reported research areas include:
- KISS1R / GPR54 receptor-binding and signaling studies
- GnRH-neuron signaling research models
- Hypothalamic-axis neuroendocrine signaling at the cell and animal level
- Structure-activity studies of kisspeptin C-terminal fragments
The existing body of work is predominantly in vitro and rodent. There are no large controlled human clinical trials establishing the compound for any therapeutic use, and it is not an FDA-approved drug. All framing here is strictly laboratory research.
QuestionsFrequently Asked Questions
What is Kisspeptin-10?
Kisspeptin-10 is a 10-amino-acid peptide (sequence YNWNSFGLRF) studied in preclinical KISS1R/GPR54-receptor and GnRH-neuron research models. It is a research compound supplied as a lyophilized powder and is not approved for human use.
What is the molecular formula of Kisspeptin-10?
The molecular formula of Kisspeptin-10 is C63H83N17O14, with a molecular weight of approximately 1302.5 g/mol (PubChem CID 25240297).
What is the CAS number for Kisspeptin-10?
The CAS registry number for Kisspeptin-10 is 374675-21-5.
What is the amino acid sequence of Kisspeptin-10?
The sequence is Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2 (single-letter: YNWNSFGLRF), a 10-residue decapeptide with a C-terminal amide.
How is Kisspeptin-10 stored and reconstituted in a research setting?
Lyophilized Kisspeptin-10 is stored at 2 to 8°C, protected from light and humidity. It is reconstituted with a suitable sterile solvent, is water-soluble, and reconstituted material is held at 4°C and used within about 30 days, avoiding repeated freeze-thaw cycles.
Is Kisspeptin-10 approved for human use?
No. Kisspeptin-10 is not an FDA-approved drug and is not intended for human consumption. It is offered strictly as a research compound for laboratory use.
For research use only. Not for human or veterinary use. Not approved by the FDA. 21+
- HPLC + MS tested, every batch
- U.S. synthesized
- Batch COA on the product page
$80View compound