KPV is a tripeptide, a chain of three amino acids (Lys-Pro-Val), corresponding to the C-terminal tripeptide sequence of alpha-melanocyte-stimulating hormone (alpha-MSH). It is studied in preclinical research as a minimal alpha-MSH-derived fragment, most often in in-vitro and animal models of cellular-signaling and melanocortin-pathway biology.
KPV is one of the smallest peptide fragments studied as a research tool for investigating alpha-MSH-related signaling, since it retains the C-terminal tripeptide motif while removing the larger parent sequence. As supplied for research, KPV is a lyophilized powder that is water-soluble on reconstitution.
Verified dataVerified compound data
| Property | Value |
|---|---|
| Compound name | KPV (Lys-Pro-Val tripeptide) |
| CAS number | 67727-97-3 |
| PubChem CID | 125672 |
| Molecular formula | C16H30N4O4 |
| Molecular weight | ~342.4 g/mol |
| Amino acid sequence | Lys-Pro-Val (KPV) |
| Length | 3 residues (tripeptide) |
| Physical form | Lyophilized powder |
Data verified against PubChem (CID 125672, C16H30N4O4) and ChemicalBook (CAS 67727-97-3).
MechanismResearch-context mechanism
In preclinical literature, KPV is studied as the C-terminal tripeptide fragment of alpha-MSH, and research has examined its interaction with melanocortin-pathway and intracellular-signaling components in cell and animal models. Reported mechanistic studies characterize KPV at the cellular and molecular level within these research models. These mechanisms are described strictly in the context of in vitro and animal research; they are not established human-use mechanisms and describe no human outcome.
Research summaryCurrent research summary
KPV appears across a cellular-signaling research literature focused on minimal alpha-MSH-derived fragments. Reported research areas include:
- Alpha-MSH-fragment structure-activity studies
- Melanocortin-pathway signaling research models (cell and animal level)
- Intracellular-signaling studies in tissue and cell models
- Comparative studies versus the full alpha-MSH sequence
The existing body of work is predominantly in vitro and rodent. There are no large controlled human clinical trials establishing the compound for any therapeutic use, and it is not an FDA-approved drug. All framing here is strictly laboratory research.
QuestionsFrequently Asked Questions
What is KPV?
KPV is a tripeptide (Lys-Pro-Val) corresponding to the C-terminal sequence of alpha-MSH, studied in preclinical cellular-signaling and melanocortin-pathway research models. It is a research compound supplied as a lyophilized powder and is not approved for human use.
What is the molecular formula of KPV?
The molecular formula of KPV is C16H30N4O4, with a molecular weight of approximately 342.4 g/mol (PubChem CID 125672).
What is the CAS number for KPV?
The CAS registry number for KPV is 67727-97-3.
What is the amino acid sequence of KPV?
KPV is the tripeptide Lys-Pro-Val (single-letter: KPV), a 3-residue fragment corresponding to the C-terminal sequence of alpha-MSH.
How is KPV stored and reconstituted in a research setting?
Lyophilized KPV is stored at 2 to 8°C, protected from light and humidity. It is reconstituted with a suitable sterile solvent, is water-soluble, and reconstituted material is held at 4°C and used within about 30 days, avoiding repeated freeze-thaw cycles.
Is KPV approved for human use?
No. KPV is not an FDA-approved drug and is not intended for human consumption. It is offered strictly as a research compound for laboratory use.
For research use only. Not for human or veterinary use. Not approved by the FDA. 21+
- HPLC + MS tested, every batch
- U.S. synthesized
- Batch COA on the product page
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