MOTS-c (mitochondrial open reading frame of the twelve S rRNA-c) is a 16-amino-acid mitochondrial-derived peptide encoded within the mitochondrial 12S rRNA region. It is studied in preclinical research as a regulatory peptide of cellular metabolism, most often in models of AMP-activated protein kinase (AMPK) signaling and metabolic-homeostasis pathways.
MOTS-c is one of a small class of mitochondrial-derived peptides studied as research tools for investigating mitochondrial-to-nuclear signaling. As supplied for research, MOTS-c is a lyophilized powder that is water-soluble on reconstitution.
Verified dataVerified compound data
| Property | Value |
|---|---|
| Compound name | MOTS-c (Mitochondrial-derived peptide) |
| PubChem CID | 176489569 |
| Molecular formula | C101H152N28O22S2 |
| Molecular weight | ~2174.6 g/mol |
| Amino acid sequence | Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg (MRWQEMGYIFYPRKLR) |
| Length | 16 residues |
| Physical form | Lyophilized powder |
Data verified against PubChem (CID 176489569 / CID 146675088, both C101H152N28O22S2, MW ~2174.6) and the published MOTS-c sequence. A discrete CAS number is not consistently registered for this peptide; it is identified here by formula, sequence, and PubChem CID.
MechanismResearch-context mechanism
In preclinical literature, MOTS-c is associated with the AMPK signaling pathway, which is studied as a regulator of cellular energy balance in research models. Studies have examined MOTS-c in relation to glucose-metabolism and metabolic-stress-response pathways at the cell and animal level. Some research models describe nuclear translocation of the peptide under metabolic stress. These mechanisms are described strictly in the context of in vitro and animal research; they are not established human-use mechanisms.
Research summaryCurrent research summary
MOTS-c appears across an emerging preclinical literature on mitochondrial-derived peptides. Reported research areas include:
- AMPK-pathway signaling studies
- Glucose- and lipid-metabolism research models
- Mitochondrial-to-nuclear signaling studies
- Metabolic-stress-response models (cell and animal level)
The existing body of work is predominantly in vitro and rodent. There are no large controlled human clinical trials establishing the compound for any therapeutic use, and it is not an FDA-approved drug. All framing here is strictly laboratory research.
QuestionsFrequently Asked Questions
What is MOTS-c?
MOTS-c is a 16-amino-acid mitochondrial-derived peptide (sequence MRWQEMGYIFYPRKLR) studied in preclinical AMPK-pathway and cellular-metabolism research models. It is a research compound supplied as a lyophilized powder and is not approved for human use.
What is the molecular formula of MOTS-c?
The molecular formula of MOTS-c is C101H152N28O22S2, with a molecular weight of approximately 2174.6 g/mol (PubChem CID 176489569).
What is the amino acid sequence of MOTS-c?
The sequence is Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg (single-letter: MRWQEMGYIFYPRKLR), a 16-residue peptide.
Does MOTS-c have a CAS number?
A discrete CAS registry number is not consistently published for MOTS-c. It is most reliably identified by its molecular formula (C101H152N28O22S2), sequence, and PubChem CID 176489569.
HandlingHow is MOTS-c stored and reconstituted in a research setting?
Lyophilized MOTS-c is stored at 2 to 8°C, protected from light and humidity. It is reconstituted with a suitable sterile solvent, is water-soluble, and reconstituted material is held at 4°C and used within about 30 days, avoiding repeated freeze-thaw cycles.
Is MOTS-c approved for human use?
No. MOTS-c is not an FDA-approved drug and is not intended for human consumption. It is offered strictly as a research compound for laboratory use.
For research use only. Not for human or veterinary use. Not approved by the FDA. 21+
- HPLC + MS tested, every batch
- U.S. synthesized
- Batch COA on the product page
