NAD+ (nicotinamide adenine dinucleotide) is a naturally occurring dinucleotide coenzyme composed of two nucleotides (one bearing a nicotinamide base, the other an adenine base) joined through a pair of phosphate groups. It is one of the most extensively studied coenzymes in biochemistry, where it functions in research models as an electron carrier in redox reactions and as a substrate examined across cellular-metabolism pathways.
Unlike a synthetic peptide, NAD+ is an endogenous metabolite present across living cells. As supplied for research, NAD+ is a lyophilized powder that is water-soluble on reconstitution. It is studied strictly as a research-grade biochemical reagent.
Verified dataVerified compound data
| Property | Value |
|---|---|
| Compound name | NAD+ (Nicotinamide adenine dinucleotide, free acid / β-NAD) |
| CAS number | 53-84-9 |
| PubChem CID | 5892 (Nadide, free acid) |
| Molecular formula | C21H27N7O14P2 (free acid) |
| Molecular weight | ~663.4 g/mol |
| Class | Dinucleotide coenzyme (not a peptide) |
| Physical form | Lyophilized powder |
Data verified against PubChem CID 5892 (Nadide) and corroborating supplier references. Note: NAD+ is indexed under multiple protonation/charge states (free acid C21H27N7O14P2 MW ~663.4; +2 cation C21H29N7O14P2+2 MW ~665.4); the free-acid values are presented here.
MechanismResearch-context mechanism
In biochemical research, NAD+ is studied as a redox cofactor that cycles between its oxidized form (NAD+) and reduced form (NADH), participating as an electron carrier in research models of cellular energy metabolism. Studies have also examined NAD+ as a substrate for enzyme families investigated in the laboratory, including sirtuin and PARP enzyme research models. These mechanisms are described strictly in the context of in vitro and animal research; they are not established human-use mechanisms.
Research summaryCurrent research summary
NAD+ appears across a broad preclinical and biochemical literature. Reported research areas include:
- Redox-cycling and electron-transfer studies (NAD+/NADH balance)
- Cellular-metabolism and mitochondrial-function research models
- Sirtuin-enzyme and PARP-enzyme substrate studies
- Aging-biology research models (studied at the cellular and animal level)
The existing body of work spans in vitro, cell-culture, and animal research. NAD+ supplied by Vantage is a research-grade reagent and is not an FDA-approved drug for any therapeutic use. All framing here is strictly laboratory research.
QuestionsFrequently Asked Questions
What is NAD+?
NAD+ (nicotinamide adenine dinucleotide) is a dinucleotide coenzyme studied in preclinical cellular-metabolism and redox-biology research models. It is supplied as a lyophilized research-grade powder and is not approved for human use.
What is the molecular formula of NAD+?
The molecular formula of the NAD+ free acid is C21H27N7O14P2, with a molecular weight of approximately 663.4 g/mol (PubChem CID 5892). NAD+ is also indexed in cationic and anionic protonation states that differ only by charge.
What is the CAS number for NAD+?
The CAS registry number for NAD+ (β-NAD, nadide) is 53-84-9.
Is NAD+ a peptide?
No. NAD+ is a dinucleotide coenzyme, not a peptide. It is composed of a nicotinamide nucleotide and an adenine nucleotide joined by phosphate groups.
How is NAD+ stored and reconstituted in a research setting?
Lyophilized NAD+ is stored at 2 to 8°C, protected from light and humidity. It is reconstituted with a suitable sterile solvent, is water-soluble, and reconstituted material is held at 4°C and used within about 30 days, avoiding repeated freeze-thaw cycles.
Is NAD+ approved for human use?
No. NAD+ supplied here is a research-grade reagent, not an FDA-approved drug, and is not intended for human consumption. It is offered strictly for laboratory use.
For research use only. Not for human or veterinary use. Not approved by the FDA. 21+
- HPLC + MS tested, every batch
- U.S. synthesized
- Batch COA on the product page
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