PT-141, also known as bremelanotide, is a synthetic cyclic heptapeptide and a melanocortin-receptor agonist. It is studied in preclinical research as a stable peptide construct, most often in models of melanocortin-receptor signaling and neuroendocrine pathway activity. PT-141 is a synthetic analog within the melanocortin peptide family and does not occur as a discrete protein in the human proteome, which makes it a fully synthetic research compound.
As supplied for research, PT-141 is a lyophilized powder that is water-soluble on reconstitution. It is handled as a research-grade material for in vitro and animal-model investigation only.
Verified dataVerified compound data
| Property | Value |
|---|---|
| Compound name | PT-141 (Bremelanotide) |
| CAS number | 189691-06-3 |
| PubChem CID | 9941379 |
| Molecular formula | C50H68N14O10 |
| Molecular weight | ~1025.2 g/mol |
| Amino acid sequence | Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH |
| Structure | Cyclic heptapeptide |
| Physical form | Lyophilized powder |
Data verified against PubChem (CID 9941379) and ChemicalBook (CAS 189691-06-3).
MechanismResearch-context mechanism
In preclinical literature, PT-141 is characterized as an agonist at melanocortin receptors, with research interest centered on the MC3R and MC4R subtypes. Studies have examined its interaction with central melanocortin signaling pathways in animal and in vitro models. These mechanisms are described strictly in the context of research models; they are not established human-use mechanisms.
Research summaryCurrent research summary
PT-141 appears in preclinical literature focused on the melanocortin system. Reported research areas include:
- Melanocortin-receptor (MC3R/MC4R) agonism in receptor-binding studies
- Central neuroendocrine-signaling research models
- Comparative studies within the melanocortin peptide family
The existing literature is preclinical and exploratory; PT-141 is supplied solely as a reference research compound.
HandlingHandling and reconstitution
PT-141 is supplied as a lyophilized powder. Reconstitute per your laboratory protocol with a suitable diluent such as a suitable sterile solvent, introduced gently down the vial wall. Store lyophilized material refrigerated at 2-8 °C, protected from light and freezing. See our peptide reconstitution protocol for general lab-handling guidance.
Every lot of Vantage Aminos PT-141 ships with a batch-specific Certificate of Analysis (HPLC purity and mass-spectrometry identity), U.S. synthesized for research use.
For research use only. Not for human or veterinary use.
- HPLC + MS tested, every batch
- U.S. synthesized
- Batch COA on the product page
$66View compound