Tesofensine (also designated NS-2330) is a small-molecule research compound, not a peptide, belonging to the phenyltropane chemical class. It is studied in preclinical research as a monoamine-reuptake inhibitor, characterized in in-vitro and animal models for its interaction with the serotonin, norepinephrine, and dopamine transporters.
Because it is a small organic molecule rather than an amino-acid chain, Tesofensine has no peptide sequence; it is identified by its molecular formula, SMILES string, CAS number, and PubChem CID. As supplied for research, it is a powder that is soluble in suitable solvents on reconstitution.
Verified dataVerified compound data
| Property | Value |
|---|---|
| Compound name | Tesofensine (NS-2330) |
| Compound class | Small molecule (phenyltropane); NOT a peptide |
| CAS number | 195875-84-4 |
| PubChem CID | 11370864 |
| Molecular formula (free base) | C17H23Cl2NO |
| Molecular weight (free base) | ~328.3 g/mol |
| SMILES | CN1[C@@H]2C[C@H](C3=CC(Cl)=C(Cl)C=C3)[C@@H](COCC)[C@H]1CC2 |
| Amino acid sequence | None: small molecule, not a peptide |
| Physical form | Powder |
Data verified against PubChem (CID 11370864, free base C17H23Cl2NO, MW ~328.3) and Cayman Chemical / Wikipedia (CAS 195875-84-4). Note: the two chlorine atoms are part of the dichlorophenyl ring of the molecule; C17H23Cl2NO is the free base, not a dihydrochloride salt. Salt forms (e.g., citrate, tartrate) are separately registered and carry different molecular weights; confirm the supplied form against the batch COA.
MechanismResearch-context mechanism
In preclinical literature, Tesofensine is studied as an inhibitor of the reuptake of three monoamine neurotransmitters (serotonin, norepinephrine, and dopamine) at their respective transporters in in-vitro and animal models. Research characterizes this transporter-interaction profile at the cellular and neuropharmacological level. These interactions are described strictly within research models; they are not established human-use mechanisms and describe no human outcome.
Research summaryCurrent research summary
Tesofensine appears in a neuropharmacology research literature focused on monoamine-transporter pharmacology. Reported research areas include:
- Serotonin / norepinephrine / dopamine reuptake-inhibition assays (in vitro)
- Monoamine-transporter binding and selectivity studies
- Central-nervous-system signaling research models (animal level)
- Phenyltropane structure-activity studies
The existing body of work spans in-vitro and animal models. There are no completed large controlled human clinical trials establishing the compound for any approved therapeutic use, and it is not an FDA-approved drug. All framing here is strictly laboratory research.
QuestionsFrequently Asked Questions
What is Tesofensine?
Tesofensine (NS-2330) is a small-molecule research compound, not a peptide, studied in preclinical research as a monoamine-reuptake inhibitor acting at the serotonin, norepinephrine, and dopamine transporters. It is supplied as a powder and is not approved for human use.
Is Tesofensine a peptide?
No. Tesofensine is a small organic molecule of the phenyltropane class. It has no amino-acid sequence and is identified by its molecular formula (free base C17H23Cl2NO), SMILES, CAS number (195875-84-4), and PubChem CID 11370864.
What is the molecular formula and weight of Tesofensine?
The free base of Tesofensine is C17H23Cl2NO with a molecular weight of approximately 328.3 g/mol (PubChem CID 11370864). The two chlorine atoms are part of the dichlorophenyl ring, not a salt counter-ion. Salt forms carry different weights. Confirm the supplied form against the batch COA.
What is the CAS number for Tesofensine?
The CAS registry number for Tesofensine (free base) is 195875-84-4.
How is Tesofensine stored in a research setting?
Tesofensine is stored as a powder at 2 to 8°C, protected from light and humidity. Reconstituted material is held at 4°C and used within about 30 days, avoiding repeated freeze-thaw cycles.
Is Tesofensine approved for human use?
No. Tesofensine is not an FDA-approved drug and is not intended for human consumption. It is offered strictly as a research compound for laboratory use.
For research use only. Not for human or veterinary use. Not approved by the FDA. 21+
- HPLC + MS tested, every batch
- U.S. synthesized
- Batch COA on the product page
$125View compound