Description
What It Is
GLP-1 Sema is a long-acting synthetic GLP-1 receptor agonist, a 31-amino-acid analog of native glucagon-like peptide-1 with fatty-acid conjugation that enables albumin binding and significantly extends plasma half-life compared to native GLP-1 (7-36 amide). It acts as a potent, selective GLP-1 receptor (GLP-1R) full agonist.
The compound is studied in metabolic research models for its characterized pharmacology at the GLP-1 receptor, its activity in pancreatic islet biology, and its signaling in hypothalamic neuroendocrine pathways. It is supplied lyophilized at 5mg per vial.
Who It’s For
Researchers in incretin biology, pancreatic endocrinology, hypothalamic neuroendocrine signaling, and GLP-1 receptor pharmacology. The long half-life profile makes it a useful tool compound for extended GLP-1R activation studies in preclinical models.
Key Research Applications
- GLP-1 receptor activation and downstream cAMP/PKA signaling
- Pancreatic beta-cell insulin secretion models (glucose-dependent)
- Hypothalamic neuroendocrine signaling pathway research
- Incretin pharmacology and GLP-1R agonist comparative studies
- Glucagon suppression and alpha-cell biology
Handling & Reconstitution
Store lyophilized GLP-1 Sema at 2 to 8°C, protected from light and moisture. Reconstitute with a suitable sterile solvent. The compound is water-soluble. Once reconstituted, store at 4°C and use within 28 days. Aliquot to avoid repeated freeze-thaw cycles.
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Disclaimer: For research use only. Not for human or veterinary use. Not approved by the FDA. 21+
