CJC-1295 No DAC, also called Modified GRF 1-29 (Mod GRF 1-29), is a synthetic analog of the first 29 amino acids of growth-hormone-releasing hormone (GHRH 1-29). It carries four amino-acid substitutions that improve stability relative to native GHRH but, unlike the DAC-bearing version, does not include the Drug Affinity Complex. Without DAC, the compound does not bind circulating albumin, giving it a short half-life and producing discrete growth-hormone pulses rather than sustained elevation in research models.
This pharmacokinetic profile makes CJC-1295 No DAC a preferred tool compound when researchers need to study pulsatile GH-secretion patterns that more closely mirror endogenous GH-release dynamics. It is supplied as a lyophilized powder and is water-soluble on reconstitution.
Verified compound data
| Property | Value |
|---|---|
| Compound name | CJC-1295 No DAC (Modified GRF 1-29 / Mod GRF 1-29) |
| CAS number | 863288-34-0 |
| PubChem CID | 56841945 (also indexed as 91976842) |
| Molecular formula | C152H252N44O42 |
| Molecular weight | ~3367.9 g/mol |
| Sequence | H-Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-NH2 |
| Length | 29 residues, C-terminal amide |
| Physical form | Lyophilized powder |
Data verified against PubChem (CID 56841945) and supplier COA / Peptpedia. The CJC-1295 with DAC variant is a different compound: PubChem CID 91971820, C165H269N47O46.
Research-context mechanism
In preclinical literature, CJC-1295 No DAC is associated with agonism at the GHRH receptor on pituitary somatotrophs. Research suggests it activates GHRH-receptor signaling to drive growth-hormone release; without albumin binding, this produces short, discrete GH pulses in animal models. Comparative pharmacokinetic studies examine it against the DAC-bearing version, which exhibits a markedly longer half-life. These mechanisms are described strictly in preclinical / animal research contexts and are not established human-use mechanisms.
Current research summary
CJC-1295 No DAC appears in GH-axis pharmacology literature, typically in:
- Pulsatile GH-secretion studies via GHRH-receptor activation
- Comparative pharmacokinetics versus CJC-1295 with DAC
- GH-axis signaling in animal models
- Synergistic secretagogue studies (commonly paired with a ghrelin-receptor agonist such as ipamorelin)
It is frequently used alongside ipamorelin in research examining combined GHRH-analog plus GH-secretagogue signaling. CJC-1295 No DAC is not an FDA-approved drug and has no established human therapeutic use.
Frequently Asked Questions
What is CJC-1295 No DAC?
CJC-1295 No DAC (Modified GRF 1-29) is a synthetic 29-residue analog of GHRH 1-29 without the Drug Affinity Complex. In research models it produces short, pulsatile growth-hormone release. It is a research compound, not for human use.
What is the difference between CJC-1295 with DAC and without DAC?
The DAC (Drug Affinity Complex) lets the peptide bind circulating albumin, extending its half-life to days. Without DAC, CJC-1295 has a short half-life and produces discrete GH pulses. They are chemically distinct: No DAC is C152H252N44O42; with DAC is C165H269N47O46.
What is the molecular formula of CJC-1295 No DAC?
The molecular formula is C152H252N44O42, with a molecular weight of approximately 3367.9 g/mol (PubChem CID 56841945).
What is the CAS number for CJC-1295 No DAC?
The CAS registry number for CJC-1295 No DAC (Modified GRF 1-29) is 863288-34-0.
What is the sequence of CJC-1295 No DAC?
The 29-residue sequence is H-Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-NH2, a Modified GRF 1-29 analog with a C-terminal amide.
Is CJC-1295 No DAC approved for human use?
No. CJC-1295 No DAC is not an FDA-approved drug and is not intended for human consumption. It is offered strictly as a research compound for laboratory use.
For research use only. Not for human or veterinary use. Not approved by the FDA. 21+
- HPLC + MS tested, every batch
- U.S. synthesized
- Batch COA on the product page
