Description
What It Is
Melanotan 2 (MT2) is a cyclic heptapeptide analog of alpha-melanocyte-stimulating hormone (alpha-MSH). It binds non-selectively to melanocortin receptors MC1R through MC5R, with particularly high affinity for MC1R and MC4R. The cyclic structure confers greater receptor binding stability compared to the linear native peptide.
MT2 is a tool compound in melanocortin receptor pharmacology and has been used in preclinical models studying melanocortin receptor subtype binding, signaling, and selectivity.
Who It’s For
Researchers studying melanocortin receptor biology, MC1R and MC4R signaling pathways, and receptor subtype selectivity. MT2 is a reference ligand in melanocortin research due to its broad receptor binding profile.
Key Research Applications
- MC1R-mediated melanogenesis pathway studies in cellular models
- MC4R signaling in central nervous system research models
- Melanocortin receptor subtype binding and selectivity studies
- Non-selective melanocortin agonist pharmacology
Handling & Reconstitution
Store lyophilized MT2 at 2 to 8°C, protected from light. Reconstitute with a suitable sterile solvent. The peptide is water-soluble. Once reconstituted, store at 4°C and use within 30 days. Light sensitivity is elevated for melanocortin peptides. Minimize exposure post-reconstitution.
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Disclaimer: For research use only. Not for human or veterinary use. Not approved by the FDA. 21+
