Description
What It Is
PT-141 (bremelanotide) is a cyclic heptapeptide derived from Melanotan 2 via removal of the C-terminal amide group. It acts as a non-selective melanocortin receptor agonist with central nervous system activity, primarily studied through its binding at MC3R and MC4R, receptors expressed in hypothalamic regions associated with a range of neuroendocrine signaling cascades.
As a research compound, PT-141 is studied in the context of melanocortin receptor pharmacology and CNS signaling biology.
Who It’s For
Researchers in melanocortin receptor biology, hypothalamic neuroendocrinology, and CNS receptor pharmacology. The compound’s CNS-active profile and MC3R/MC4R selectivity make it a tool compound for studies focusing on central melanocortin signaling.
Key Research Applications
- MC3R and MC4R binding and downstream CNS signaling studies
- Hypothalamic melanocortin pathway research
- Neuroendocrine receptor pharmacology
- Comparative melanocortin agonist studies (vs. alpha-MSH, MT2)
Handling & Reconstitution
Store lyophilized PT-141 at 2 to 8°C, protected from light. Reconstitute with a suitable sterile solvent. The peptide is water-soluble. Once reconstituted, store at 4°C and use within 30 days. Aliquot before freezing to minimize degradation.
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Disclaimer: For research use only. Not for human or veterinary use. Not approved by the FDA. 21+
