5-Amino-1MQ (5-amino-1-methylquinolinium) is a small-molecule research compound, not a peptide, built on a methylquinolinium core, with a methyl group on the ring nitrogen and an amino substituent at the 5-position. It is studied in preclinical research as a substrate-site-targeting inhibitor of the enzyme nicotinamide N-methyltransferase (NNMT), most often in in-vitro enzyme-assay and cell-model contexts.
Because it is a small organic molecule rather than an amino-acid chain, 5-Amino-1MQ has no peptide sequence; it is identified by its molecular formula, SMILES string, CAS number, and PubChem CID. The active species is the 5-amino-1-methylquinolinium cation, and research material is typically supplied as a salt, commonly the iodide or chloride form. As supplied for research, it is a powder that is soluble on reconstitution.
Verified dataVerified compound data
| Property | Value |
|---|---|
| Compound name | 5-Amino-1MQ (5-amino-1-methylquinolinium) |
| Compound class | Small molecule (methylquinolinium); NOT a peptide |
| CAS number | 42464-96-0 (cation / parent designation) |
| PubChem CID | 950107 (cation, C10H11N2+) |
| Molecular formula (active cation) | C10H11N2+ |
| Molecular weight (cation) | ~159.2 g/mol |
| Common salt forms (flagged) | Iodide: C10H11IN2, MW ~286.1 (CID/supplier) · Chloride: C10H11ClN2, MW ~194.7 |
| SMILES (cation) | C[n+]1cccc2c(N)cccc12 |
| Amino acid sequence | None: small molecule, not a peptide |
| Physical form | Powder (salt form) |
Data verified against PubChem (CID 950107, cation C10H11N2+, MW ~159.2) and ChemicalBook / Sigma-Aldrich (CAS 42464-96-0; iodide salt listing). Note: reported molecular weight varies by salt form. The active cation is ~159.2 g/mol, the iodide salt ~286.1 g/mol, and the chloride salt ~194.7 g/mol. Always confirm the supplied salt form against the batch COA.
MechanismResearch-context mechanism
In preclinical literature, 5-Amino-1MQ is studied as a substrate-site-targeting, selective inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme involved in nicotinamide metabolism. Research characterizes its NNMT-inhibition activity in in-vitro enzyme assays and cell models. These interactions are described at the enzyme and cellular level in research models only; they are not established human-use mechanisms and describe no human outcome.
Research summaryCurrent research summary
5-Amino-1MQ appears in an enzyme-inhibition research literature focused on NNMT. Reported research areas include:
- NNMT enzyme-inhibition assays (in vitro)
- Nicotinamide-metabolism pathway studies in cell models
- Structure-activity studies of methylquinolinium NNMT inhibitors
- Cellular-metabolism research models (cell and animal level)
The existing body of work is predominantly in vitro and rodent. There are no large controlled human clinical trials establishing the compound for any therapeutic use, and it is not an FDA-approved drug. All framing here is strictly laboratory research.
QuestionsFrequently Asked Questions
What is 5-Amino-1MQ?
5-Amino-1MQ (5-amino-1-methylquinolinium) is a small-molecule research compound, not a peptide, studied in preclinical research as a substrate-site-targeting inhibitor of the enzyme NNMT. It is supplied as a powder (salt form) and is not approved for human use.
Is 5-Amino-1MQ a peptide?
No. 5-Amino-1MQ is a small organic molecule based on a methylquinolinium core. It has no amino-acid sequence and is identified by its molecular formula (active cation C10H11N2+), SMILES, CAS number (42464-96-0), and PubChem CID 950107.
What is the molecular formula and weight of 5-Amino-1MQ?
The active 5-amino-1-methylquinolinium cation is C10H11N2+ with a molecular weight of approximately 159.2 g/mol (PubChem CID 950107). Reported weights vary by salt form: the iodide salt is ~286.1 g/mol and the chloride salt ~194.7 g/mol. Confirm the supplied salt against the batch COA.
What is the CAS number for 5-Amino-1MQ?
The CAS registry number associated with 5-Amino-1MQ is 42464-96-0.
How is 5-Amino-1MQ stored in a research setting?
5-Amino-1MQ is stored as a powder at 2 to 8°C, protected from light and humidity. Reconstituted material is held at 4°C and used within about 30 days, avoiding repeated freeze-thaw cycles.
Is 5-Amino-1MQ approved for human use?
No. 5-Amino-1MQ is not an FDA-approved drug and is not intended for human consumption. It is offered strictly as a research compound for laboratory use.
For research use only. Not for human or veterinary use. Not approved by the FDA. 21+
- HPLC + MS tested, every batch
- U.S. synthesized
- Batch COA on the product page
$91View compound