Tesofensine and 5-Amino-1MQ are both studied in metabolic research models, but they act through entirely different mechanisms: central monoamine reuptake versus a metabolic enzyme.
At a glance
| Property | Tesofensine | 5-Amino-1MQ |
|---|---|---|
| Class | Triple monoamine reuptake inhibitor | Small-molecule NNMT inhibitor |
| Primary research target | DA / NE / 5-HT transporters | NNMT enzyme |
| Research domain | Monoamine-transporter signaling | NAD+ / adipocyte metabolism |
| Structure | Small molecule | Small molecule |
| Format | Lyophilized powder | Lyophilized powder |
Tesofensine in research
Tesofensine is studied as a triple monoamine (dopamine, norepinephrine, serotonin) reuptake inhibitor in central appetite- and monoamine-signaling research models. See the full Tesofensine research profile.
5-Amino-1MQ in research
5-Amino-1MQ is studied as an inhibitor of NNMT in NAD+ and adipocyte-metabolism research models. See the full 5-Amino-1MQ research profile.
Key differences
- Tesofensine acts on central monoamine transporters; 5-Amino-1MQ inhibits the NNMT enzyme.
- Both appear in metabolic research but via CNS versus enzymatic mechanisms.
- Both are supplied as lyophilized research compounds.
Selecting for a research model
Researchers select between Tesofensine and 5-Amino-1MQ based on whether a central monoamine or a peripheral metabolic-enzyme mechanism fits the model. These distinctions are described strictly in the context of research models and are not statements of efficacy, safety, or suitability for any use.
Both Tesofensine and 5-Amino-1MQ ship from Vantage Aminos with a batch-specific Certificate of Analysis (HPLC purity and mass-spectrometry identity), U.S. synthesized for research use.
For research use only. Not for human or veterinary use.
- HPLC + MS tested, every batch
- U.S. synthesized
- Batch COA on the product page
